Molecular mechanisms of resistance to antifolates, a review.

Medicine & Life Sciences

• 5,6,7,8-tetrahydrofolic acid 8%
• bcl-1 Genes 7%
• Binding Sites 4%
• Breast Neoplasms 3%
• Cell Cycle 4%
• Cell Line 6%
• Choriocarcinoma 6%
• Cyclin D1 5%
• dihydrofolate 8%
• Drug Resistance 4%
• E2F Transcription Factors 7%
• Enzymes 5%
• Fibrosarcoma 6%
• Folic Acid 10%
• Folic Acid Antagonists 94%
• folylpolyglutamate synthetase 9%
• Gene Amplification 6%
• Genes 10%
• Genetic Promoter Regions 5%
• Head 3%
• Methotrexate 66%
• Neck 4%
• Neoplasms 1%
• Non-Hodgkin's Lymphoma 4%
• Organism Cloning 4%
• Osteosarcoma 5%
• Pharmaceutical Preparations 4%
• Phenotype 3%
• Point Mutation 5%
• Polyglutamic Acid 8%
• Precursor Cell Lymphoblastic Leukemia-Lymphoma 5%
• Proteins 3%
• Retinoblastoma 12%
• Retinoblastoma Genes 14%
• Tetrahydrofolate Dehydrogenase 63%
• Therapeutics 0%

Chemical Compounds

• Antifolate 100%
• Antineoplastic Agent 4%
• Binding Site 3%
• Dihydrofolates 59%
• Drug 8%
• Enzyme Activity 4%
• Folate 12%
• Methotrexate 85%
• Mutation 4%
• Protein 4%
• Reduction 2%
• Resistance 43%