Molecular determinants of drug resistance in tuberculosis

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90 Scopus citations


Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.

Original languageEnglish (US)
Pages (from-to)S4-S10
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number2 SUPPL. 1
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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