TY - JOUR
T1 - Molecular cytogenetics of mouse models of breast cancer
AU - Ried, Thomas
AU - Dorritie, Kathy
AU - Weaver, Zoë
AU - Wangsa, Danny
AU - Difilippantonio, Michael J.
AU - Montagna, Cristina
PY - 2004
Y1 - 2004
N2 - In summary, the comprehensive molecular cytogenetic analysis of mouse models of breast cancers has shown that tumorigenesis requires, as in human cancers, the acquisition of distinct genomic imbalances. Some of these imbalances are common to all analyzed mouse models, such as frequent copy number losses on chromosome 4. However, distinct differences exist as well. The projection of the maps of genomic imbalances identified in human breast carcinomas onto the mouse genome shows that a considerable proportion of genomic imbalances occur in both species, however, the comparative maps do not result in "mirror" images of genomic imbalances. That being said, the BRCA1-associated mouse tumors reveal a distribution of genomic imbalances and a level of genomic instability that is most similar to human breast cancers.
AB - In summary, the comprehensive molecular cytogenetic analysis of mouse models of breast cancers has shown that tumorigenesis requires, as in human cancers, the acquisition of distinct genomic imbalances. Some of these imbalances are common to all analyzed mouse models, such as frequent copy number losses on chromosome 4. However, distinct differences exist as well. The projection of the maps of genomic imbalances identified in human breast carcinomas onto the mouse genome shows that a considerable proportion of genomic imbalances occur in both species, however, the comparative maps do not result in "mirror" images of genomic imbalances. That being said, the BRCA1-associated mouse tumors reveal a distribution of genomic imbalances and a level of genomic instability that is most similar to human breast cancers.
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U2 - 10.3233/BD-2004-19108
DO - 10.3233/BD-2004-19108
M3 - Article
C2 - 15687698
AN - SCOPUS:8444253285
SN - 0888-6008
VL - 19
SP - 59
EP - 67
JO - Breast Disease
JF - Breast Disease
ER -