Molecular basis of combined pituitary hormone deficiencies

Laurie E. Cohen, Sally Radovick

Research output: Contribution to journalReview articlepeer-review

191 Scopus citations


Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.

Original languageEnglish (US)
Pages (from-to)431-442
Number of pages12
JournalEndocrine reviews
Issue number4
StatePublished - Aug 2002
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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