Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death

Ischemic stroke is the leading cause of long-term disability in adults. The primary reason for the disability is the death of neurons in the cortex or subcortical nuclei. Following cerebral ischemia, neurons may die of accidental cell death (necrosis) or regulated cell death such as apoptosis, necroptosis, or ferroptosis. In this chapter, we summarize recent progress in the molecular and cellular mechanisms of ischemic neuronal death. A better understanding of the mechanisms of ischemic neuronal death, especially regulated cell death, may promote the development of therapeutic intervention of ischemic stroke.