TY - JOUR
T1 - Modulating Copper Reactivity
T2 - A New Approach to Reprogram Mitochondrial Retrograde Signaling
AU - Zacharioudakis, Emmanouil
N1 - Publisher Copyright:
© Published 2023 by American Chemical Society.
PY - 2023
Y1 - 2023
N2 - The crosstalk between mitochondria and the nucleus regulates cell plasticity and innate immune response. A new study shows that copper(II) accumulates in mitochondria of activated macrophages in response to pathogen infection and induces metabolic and epigenetic reprogramming that promotes inflammation. Pharmacologic targeting of mitochondrial copper(II) uncovers a new therapeutic strategy to combat aberrant inflammation and regulate cell plasticity.
AB - The crosstalk between mitochondria and the nucleus regulates cell plasticity and innate immune response. A new study shows that copper(II) accumulates in mitochondria of activated macrophages in response to pathogen infection and induces metabolic and epigenetic reprogramming that promotes inflammation. Pharmacologic targeting of mitochondrial copper(II) uncovers a new therapeutic strategy to combat aberrant inflammation and regulate cell plasticity.
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U2 - 10.1021/acschembio.3c00298
DO - 10.1021/acschembio.3c00298
M3 - Article
C2 - 37289036
AN - SCOPUS:85163490213
SN - 1554-8929
JO - ACS Chemical Biology
JF - ACS Chemical Biology
ER -