TY - GEN
T1 - Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate
AU - Sarma, Sridevi V.
AU - Cheng, Ming
AU - Eden, Uri
AU - Hu, Rollin
AU - Williams, Ziv
AU - Brown, Emery N.
AU - Eskandar, Emad
PY - 2008
Y1 - 2008
N2 - How neurons encode information about the outside world and how this processing changes when the brain is diseased are central questions in neuroscience and medicine. Historically, microelectrode recordings of single-unit neuronal activity have been confined to animal preparations. Recently, it has become possible to obtain single-unit recordings in humans undergoing deep brain stimulation surgery. In this study, we recorded neuronal activity from the sub-thalamic nucleus (STN) of the basal ganglia of patients with Parkinson's disease (PD). In parallel, identical experiments were conducted on a healthy primate, providing a rare opportunity to analyze STN neuronal activity recorded in both the disease and healthy state during the same behavioral tasks. We developed point process models of STN neurons to capture neural spiking dynamics as a function of extrinsic stimuli and the neuron's own spiking history. Although our findings are preliminary due to only one primate subject, we found pathological signatures in PD neural activity (not found in the primate) such as bursting, 10-30Hz oscillations, and directional tuning prior to movement, which may directly relate to motor disorders observed in PD patients such as bradykinesia, resting tremor and rigidity.
AB - How neurons encode information about the outside world and how this processing changes when the brain is diseased are central questions in neuroscience and medicine. Historically, microelectrode recordings of single-unit neuronal activity have been confined to animal preparations. Recently, it has become possible to obtain single-unit recordings in humans undergoing deep brain stimulation surgery. In this study, we recorded neuronal activity from the sub-thalamic nucleus (STN) of the basal ganglia of patients with Parkinson's disease (PD). In parallel, identical experiments were conducted on a healthy primate, providing a rare opportunity to analyze STN neuronal activity recorded in both the disease and healthy state during the same behavioral tasks. We developed point process models of STN neurons to capture neural spiking dynamics as a function of extrinsic stimuli and the neuron's own spiking history. Although our findings are preliminary due to only one primate subject, we found pathological signatures in PD neural activity (not found in the primate) such as bursting, 10-30Hz oscillations, and directional tuning prior to movement, which may directly relate to motor disorders observed in PD patients such as bradykinesia, resting tremor and rigidity.
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U2 - 10.1109/CDC.2008.4738693
DO - 10.1109/CDC.2008.4738693
M3 - Conference contribution
AN - SCOPUS:62949239871
SN - 9781424431243
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 2012
EP - 2017
BT - Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 47th IEEE Conference on Decision and Control, CDC 2008
Y2 - 9 December 2008 through 11 December 2008
ER -