@article{c404928e1f21462c91157a90d53133a8,
title = "Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: Deriving EEG-based neuro-markers during a dual-task walking study",
abstract = "Objective: Individuals with a diagnosis of multiple sclerosis (MS) often present with cognitive and motor deficits, and thus the ability to perform tasks that rely on both domains may be particularly impaired. Yet, dual-task walking studies yield mixed results. Individual variance in the ability to cope with brain insult and mobilize additional brain resources may contribute to mixed findings. Methods: To test this hypothesis, we acquired event-related potentials (ERP) in individuals with MS and healthy controls (HCs) performing a Go/NoGo task while sitting (i.e., single task) or walking (i.e., dual-task) and looked at the relationship between task related modulation of the brain response and performance. Results: On the Go/NoGo task the MS group showed dual-task costs when walking, whereas HCs showed a dual-task benefit. Further, whereas the HC group showed modulation of the brain response as a function of task load, this was not the case in the MS group. Analysis for the pooled sample revealed a positive correlation between load-related ERP effects and dual-task performance. Conclusions: These data suggest a neurophysiological marker of cognitive-motor dysfunction in MS. Significance: Understanding neural processes underlying dual-task walking will help identify objective brain measurements of real-world issues and may improve assessment of MS.",
keywords = "Dual-task walking, EEG, Mobile Brain/Body Imaging (MoBI), Multiple sclerosis",
author = "{De Sanctis}, Pierfilippo and Malcolm, {Brenda R.} and Mabie, {Peter C.} and Francisco, {Ana A.} and Mowrey, {Wenzhu B.} and Sonja Joshi and Sophie Molholm and Foxe, {John J.}",
note = "Funding Information: The primary sources of funding for this work was provided by a pilot grant from the National Multiple Sclerosis Society United States ( PP3398 ) and by a Mentored Research Scientist Development Award from the National Institute on Aging United States ( 5K01AG049991 ). Furthermore, this work was supported by the CDMRP (Congressionally Directed Medical Research Programs) United States, through the Multiple Sclerosis Research Program under Award No. W81XWH-17-1-0105. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. Participant recruitment was performed by the Human Clinical Phenotyping Core at Einstein, a facility of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) which is funded by a center grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development ( NICHD U54 HD090260 ). Funding Information: The primary sources of funding for this work was provided by a pilot grant from the National Multiple Sclerosis Society United States (PP3398) and by a Mentored Research Scientist Development Award from the National Institute on Aging United States (5K01AG049991). Furthermore, this work was supported by the CDMRP (Congressionally Directed Medical Research Programs) United States, through the Multiple Sclerosis Research Program under Award No. W81XWH-17-1-0105. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. Participant recruitment was performed by the Human Clinical Phenotyping Core at Einstein, a facility of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) which is funded by a center grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD U54 HD090260). We thank our participants for their willingness to volunteer for this study. We also extend out thanks to the neuropsychologist, research technician and former interns who helped with assessments and EEG data collection: Dr. Pamela Counts (neuropsychologist), Gregory Peters (technician), Katalina Gomez (intern), and Dr. Elizabeth Chernyak (intern). All authors declare no conflicts of interest, financial or otherwise. Publisher Copyright: {\textcopyright} 2020 International Federation of Clinical Neurophysiology",
year = "2020",
month = may,
doi = "10.1016/j.clinph.2020.01.024",
language = "English (US)",
volume = "131",
pages = "1119--1128",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "5",
}