MNGIE neuropathy: Five cases mimicking chrohic inflammatory demyelinating polyneuropathy

Richard S. Bedlack; Tuan Vu; Simon Hammans; Steven A. Sparr; Bennett Myers; Joel Morgenlander; Michio Hirano

doi:10.1002/mus.10546

MNGIE neuropathy: Five cases mimicking chrohic inflammatory demyelinating polyneuropathy

Richard S. Bedlack, Tuan Vu, Simon Hammans, Steven A. Sparr, Bennett Myers, Joel Morgenlander, Michio Hirano

Neurology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGIE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. In fact, three patients were actually treated for chronic inflammatory demyelinating polyneuropathy (CIDP). We discuss findings that may help distinguish patients with MNGIE from those with CIDP.

Original language	English (US)
Pages (from-to)	364-368
Number of pages	5
Journal	Muscle and Nerve
Volume	29
Issue number	3
DOIs	https://doi.org/10.1002/mus.10546
State	Published - Mar 2004

Keywords

Demyelination
Inflammation
Mitochondria
Mitochondrial myopathy
Peripheral neuropathy
Thymidine phosphorylase

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.10546

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abstract = "We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGIE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. In fact, three patients were actually treated for chronic inflammatory demyelinating polyneuropathy (CIDP). We discuss findings that may help distinguish patients with MNGIE from those with CIDP.",

keywords = "Demyelination, Inflammation, Mitochondria, Mitochondrial myopathy, Peripheral neuropathy, Thymidine phosphorylase",

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AU - Hammans, Simon

AU - Sparr, Steven A.

AU - Myers, Bennett

AU - Morgenlander, Joel

AU - Hirano, Michio

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AB - We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGIE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. In fact, three patients were actually treated for chronic inflammatory demyelinating polyneuropathy (CIDP). We discuss findings that may help distinguish patients with MNGIE from those with CIDP.

KW - Demyelination

KW - Inflammation

KW - Mitochondria

KW - Mitochondrial myopathy

KW - Peripheral neuropathy

KW - Thymidine phosphorylase

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MNGIE neuropathy: Five cases mimicking chrohic inflammatory demyelinating polyneuropathy

Abstract

Keywords

ASJC Scopus subject areas

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