Mixed Transcortical Aphasia in Nonfamilial Dysphasic Dementia

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16 Scopus citations


The neurolinguistic and cognitive profiles of a patient with nixed transcortical aphasia and non-familial dysphasic dementia associated with progressive, left perisylvian involution are presented. This clinicopathological entity has recently been shown to be an example of a novel class of intrinsic, focal cortical degenerations with sparing of the basal forebrain. The characteristics of the aphasia were unusual. There where occasional and verbal paraphasic errors, but no completion phenomenon, embellishment or significant ecliolalia. Evidence of a generalized lexical disruption was found on detailed anayanalysis of residual abilities it reading, writing and spelling. A newly described from of non-lexical repetition was present, resulting in the patient's inability to correct syntactical and semantic errors. Affective prosodic repetition was intact. A combined paraphasic wordproduction and semantic anomia was found. These observations combined with evidence process of evolving region-specific cognitive impairments suggest that the pathological resulted in a relative disconnection of integral frontal and parieto-occipital areas from adjacent perisylvian anguage zones.

Original languageEnglish (US)
Pages (from-to)545-554
Number of pages10
Issue number4
StatePublished - 1988

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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