TY - JOUR
T1 - Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck
AU - Vogl, Steven E.
AU - Lerner, Harvey
AU - Kaplan, Barry H.
AU - Camacho, Fernando
AU - Cinberg, James
AU - Schoenfeld, David
PY - 1982/7/1
Y1 - 1982/7/1
N2 - Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.
AB - Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.
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U2 - 10.1002/1097-0142(19820701)50:1<6::AID-CNCR2820500103>3.0.CO;2-H
DO - 10.1002/1097-0142(19820701)50:1<6::AID-CNCR2820500103>3.0.CO;2-H
M3 - Article
C2 - 6177393
AN - SCOPUS:0019993789
SN - 0008-543X
VL - 50
SP - 6
EP - 9
JO - Cancer
JF - Cancer
IS - 1
ER -