Mitochondrial DNA mutations and aging: A case closed?

Konstantin Khrapko, Jan Vijg

Research output: Contribution to journalShort surveypeer-review

44 Scopus citations


Recent reports of premature aging in mutant mice with greatly increased rates of mitochondrial DNA mutagenesis (so-called 'mitochondrial mutator mice') appeared to confirm that accumulation of mtDNA mutations is a key mechanism of normal aging. Now, in a dramatic turnaround, a new study reports that levels of point mutations in tissues of aged normal mice are much lower than in the mutator mice, apparently ruling out a causal role in normal aging.

Original languageEnglish (US)
Pages (from-to)445-446
Number of pages2
JournalNature Genetics
Issue number4
StatePublished - Apr 2007
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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