TY - JOUR
T1 - MiRNA-148b and its role in various cancers
AU - Dorraki, Najmeh
AU - Ghale-Noie, Zari Naderi
AU - Ahmadi, Nooshin Sadegh
AU - Keyvani, Vahideh
AU - Bahadori, Rosita Azar
AU - Nejad, Arash Salmani
AU - Aschner, Michael
AU - Pourghadamyari, Hossein
AU - Mollazadeh, Samaneh
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2021 Future Medicine Ltd.
PY - 2021/12
Y1 - 2021/12
N2 - miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.
AB - miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.
KW - biomarker
KW - cancers
KW - miR-148b
KW - signaling pathway
KW - target genes
UR - http://www.scopus.com/inward/record.url?scp=85121047476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121047476&partnerID=8YFLogxK
U2 - 10.2217/epi-2021-0155
DO - 10.2217/epi-2021-0155
M3 - Review article
C2 - 34852637
AN - SCOPUS:85121047476
SN - 1750-1911
VL - 13
SP - 1939
EP - 1960
JO - Epigenomics
JF - Epigenomics
IS - 24
ER -