@article{a2d41baff4724922a9b7bd4f230e9ef9,
title = "MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs",
abstract = "Long non-coding RNAs (lncRNAs) regulate vital biological processes, including cell proliferation, differentiation and development. A subclass of lncRNAs is synthesized from microRNA (miRNA) host genes (MIRHGs) due to pre-miRNA processing, and are categorized as miRNA-host gene lncRNAs (lnc-miRHGs). Presently, the cellular function of most lnc-miRHGs is not well understood. We demonstrate a miRNA-independent role for a nuclear-enriched lnc-miRHG in cell cycle progression. MIR100HG produces spliced and stable lncRNAs that display elevated levels during the G1 phase of the cell cycle. Depletion of MIR100HG-encoded lncRNAs in human cells results in aberrant cell cycle progression without altering the levels of miRNA encoded within MIR100HG. Notably, MIR100HG interacts with HuR/ELAVL1 as well as with several HuR-target mRNAs. Further, MIR100HG-depleted cells show reduced interaction between HuR and three of its target mRNAs, indicating that MIR100HG facilitates interaction between HuR and target mRNAs. Our studies have unearthed novel roles played by a MIRHG-encoded lncRNA in regulating RNA binding protein activity, thereby underscoring the importance of determining the function of several hundreds of lnc-miRHGs that are present in human genome.",
author = "Qinyu Sun and Vidisha Tripathi and Yoon, {Je Hyun} and Singh, {Deepak K.} and Qinyu Hao and Min, {Kyung Won} and Sylvia Davila and Zealy, {Richard W.} and Li, {Xiao Ling} and Maria Polycarpou-Schwarz and Elin Lehrmann and Yongqing Zhang and Becker, {Kevin G.} and Freier, {Susan M.} and Yuelin Zhu and Sven Diederichs and Prasanth, {Supriya G.} and Ashish Lal and Myriam Gorospe and Prasanth, {Kannanganattu V.}",
note = "Funding Information: National Institute of Health [1RO1GM088252 to K.V.P., 1RO1GM099669 to S.G.P.]; American Cancer Society [RSG-11-174-01-RMC to K.V.P.]; National Science Foundation [career, 1243372 to S.G.P. and EAGER 1723008 to K.V.P.]; National Institute on Aging intramural Research Program, NIH [Z01-AG000511 to M.G.]; Medical University of South Carolina and Hollings Cancer Center (to J.H.Y.); National Institute on Cancer Intramural Research Program, NIH (to A.L.). The funders had no role in study design, data collection and analysis. Funding for open access charge: Start-up grant from UIUC. Funding Information: National Institute of Health [1RO1GM088252 to K.V.P., 1RO1GM099669 to S.G.P.]; American Cancer Society [RSG-11-174-01-RMC to K.V.P.]; National Science Foundation [career, 1243372 to S.G.P. and EAGER 1723008 to K.V.P.]; National Institute on Aging intramural Research Program, NIH [Z01-AG000511 to M.G.]; Medical University of South Carolina and Hollings Cancer Center (to J.H.Y.); National Institute on Cancer Intramural Research Program, NIH (to A.L.). The funders had no role in study design, data collection and analysis. Funding for open access charge: Start-up grant from UIUC. Conflict of interest statement. S.M.F. is an employee of Ionis Pharmaceuticals, and receives salary from the company. Publisher Copyright: {\textcopyright} The Author(s)",
year = "2018",
month = nov,
day = "2",
doi = "10.1093/nar/gky696",
language = "English (US)",
volume = "46",
pages = "10405--10416",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "19",
}