Migraine: Epidemiology, Burden, and Comorbidity

Rebecca C. Burch, Dawn C. Buse, Richard B. Lipton

Research output: Contribution to journalReview articlepeer-review

289 Scopus citations


Migraine affects an estimated 12% of the population. Global estimates are higher. Chronic migraine (CM) affects 1% to 2% of the global population. Approximately 2.5% of persons with episodic migraine progress to CM. Several risk factors are associated with the progression to CM. There is significant short-term variability in migraine frequency independent of treatment. Migraine is associated with cardiovascular disease, psychiatric disease, and sleep disorders. It is the second most disabling condition worldwide. CM is associated with higher headache-related disability/impact, medical and psychiatric comorbidities, health care resource use, direct and indirect costs, lower socioeconomic status, and health-related quality of life.

Original languageEnglish (US)
Pages (from-to)631-649
Number of pages19
JournalNeurologic Clinics
Issue number4
StatePublished - Nov 2019


  • Chronic migraine (CM)
  • Comorbidity
  • Headache-related disability
  • Incidence
  • Migraine
  • Prevalence
  • Progression
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology


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