Microwave assisted synthesis of caffeine/maleic acid co-crystals: The role of the dielectric and physicochemical properties of the solvent

Sudhir Pagire; Sachin Korde; Rohan Ambardekar; Shivprasad Deshmukh; Radha Charan Dash; Ravindra Dhumal; Anant Paradkar

doi:10.1039/c3ce40292d

Microwave assisted synthesis of caffeine/maleic acid co-crystals: The role of the dielectric and physicochemical properties of the solvent

Sudhir Pagire, Sachin Korde, Rohan Ambardekar, Shivprasad Deshmukh, Radha Charan Dash, Ravindra Dhumal, Anant Paradkar

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

In the present work microwave radiation has been used to prepare the 1 1 and 2 1 co-crystals of caffeine and maleic acid. We obtained 1 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.

Original language	English (US)
Pages (from-to)	3705-3710
Number of pages	6
Journal	CrystEngComm
Volume	15
Issue number	18
DOIs	https://doi.org/10.1039/c3ce40292d
State	Published - May 14 2013
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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abstract = "In the present work microwave radiation has been used to prepare the 1 1 and 2 1 co-crystals of caffeine and maleic acid. We obtained 1 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.",

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AU - Pagire, Sudhir

AU - Korde, Sachin

AU - Ambardekar, Rohan

AU - Deshmukh, Shivprasad

AU - Dash, Radha Charan

AU - Dhumal, Ravindra

AU - Paradkar, Anant

PY - 2013/5/14

Y1 - 2013/5/14

N2 - In the present work microwave radiation has been used to prepare the 1 1 and 2 1 co-crystals of caffeine and maleic acid. We obtained 1 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.

AB - In the present work microwave radiation has been used to prepare the 1 1 and 2 1 co-crystals of caffeine and maleic acid. We obtained 1 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.

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Microwave assisted synthesis of caffeine/maleic acid co-crystals: The role of the dielectric and physicochemical properties of the solvent

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