Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives

Alessandro F. Valdez; Daniel Zamith-Miranda; Leonardo Nimrichter; Joshua D. Nosanchuk

doi:10.2217/fmb-2023-0079

Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives

Alessandro F. Valdez, Daniel Zamith-Miranda, Leonardo Nimrichter, Joshua D. Nosanchuk

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Among the pharmacological limitations of conventional systemic and topical antifungal therapy are problems associated with low bioavailability, lack of selectivity and high toxicity. Micro- and nanodrug delivery systems are an interesting alternative, mainly because they offer a chance to neutralize these limitations as the pharmacological agent is dissolved, entrapped, encapsulated or bound to a matrix of particles, thus functioning as controlled and specific drug-delivery systems.

Original language	English (US)
Pages (from-to)	1007-1011
Number of pages	5
Journal	Future Microbiology
Volume	18
Issue number	15
DOIs	https://doi.org/10.2217/fmb-2023-0079
State	Published - Nov 1 2023

Keywords

Candida
dermatophytosis
fungal infection
microparticles
nanoparticles
nitric oxide
onychomycosis
trichophyton

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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title = "Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives",

abstract = "Among the pharmacological limitations of conventional systemic and topical antifungal therapy are problems associated with low bioavailability, lack of selectivity and high toxicity. Micro- and nanodrug delivery systems are an interesting alternative, mainly because they offer a chance to neutralize these limitations as the pharmacological agent is dissolved, entrapped, encapsulated or bound to a matrix of particles, thus functioning as controlled and specific drug-delivery systems.",

keywords = "Candida, dermatophytosis, fungal infection, microparticles, nanoparticles, nitric oxide, onychomycosis, trichophyton",

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AU - Valdez, Alessandro F.

AU - Zamith-Miranda, Daniel

AU - Nimrichter, Leonardo

AU - Nosanchuk, Joshua D.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Among the pharmacological limitations of conventional systemic and topical antifungal therapy are problems associated with low bioavailability, lack of selectivity and high toxicity. Micro- and nanodrug delivery systems are an interesting alternative, mainly because they offer a chance to neutralize these limitations as the pharmacological agent is dissolved, entrapped, encapsulated or bound to a matrix of particles, thus functioning as controlled and specific drug-delivery systems.

AB - Among the pharmacological limitations of conventional systemic and topical antifungal therapy are problems associated with low bioavailability, lack of selectivity and high toxicity. Micro- and nanodrug delivery systems are an interesting alternative, mainly because they offer a chance to neutralize these limitations as the pharmacological agent is dissolved, entrapped, encapsulated or bound to a matrix of particles, thus functioning as controlled and specific drug-delivery systems.

KW - Candida

KW - dermatophytosis

KW - fungal infection

KW - microparticles

KW - nanoparticles

KW - nitric oxide

KW - onychomycosis

KW - trichophyton

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JO - Future Microbiology

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ER -

Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives

Abstract

Keywords

ASJC Scopus subject areas

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