Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders?

Josephine Elia; Breck G. Borcherding; Judith L. Rapoport; Cynthia S. Keysor

doi:10.1016/0165-1781(91)90126-A

Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders?

Josephine Elia, Breck G. Borcherding, Judith L. Rapoport, Cynthia S. Keysor

Research output: Contribution to journal › Article › peer-review

267 Scopus citations

Abstract

The response to stimulant drugs of 48 boys with attention deficit/hyperactivity disorder was measured following dextroamphetamine, methylphenidate, and placebo in a double-blind crossover study. To distinguish lack of behavioral improvement from adverse drug effects, a day hospital setting and a wide dose range were used. Both drugs were highly and equally efficacious for the group as a whole, and frequently one drug or the other was superior for an individual child, or adverse effects occured only on one of the stimulants. Only one of the 48 boys (2%) was discharged without the recommendation for continued stimulant drug treatment. "Nonresponse" appears to be extremely rare when both stimulants and a wide range of doses are given.

Original language	English (US)
Pages (from-to)	141-155
Number of pages	15
Journal	Psychiatry Research
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(91)90126-A
State	Published - Feb 1991
Externally published	Yes

Keywords

Stimulants
dextroamphetamine
hyperactivity
methylphenidate

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(91)90126-A

Cite this

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AU - Elia, Josephine

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AU - Rapoport, Judith L.

AU - Keysor, Cynthia S.

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AB - The response to stimulant drugs of 48 boys with attention deficit/hyperactivity disorder was measured following dextroamphetamine, methylphenidate, and placebo in a double-blind crossover study. To distinguish lack of behavioral improvement from adverse drug effects, a day hospital setting and a wide dose range were used. Both drugs were highly and equally efficacious for the group as a whole, and frequently one drug or the other was superior for an individual child, or adverse effects occured only on one of the stimulants. Only one of the 48 boys (2%) was discharged without the recommendation for continued stimulant drug treatment. "Nonresponse" appears to be extremely rare when both stimulants and a wide range of doses are given.

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Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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