TY - JOUR
T1 - Metal-induced neurodegeneration in C. elegans
AU - Chen, Pan
AU - Martinez-Finley, Ebany J.
AU - Bornhorst, Julia
AU - Chakraborty, Sudipta
AU - Aschner, Michael
PY - 2013
Y1 - 2013
N2 - The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60-80% of human genes and contain genes involved in metal homeostasis and transport, allowing for the study of metal-induced degeneration in the nematode. This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm.
AB - The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60-80% of human genes and contain genes involved in metal homeostasis and transport, allowing for the study of metal-induced degeneration in the nematode. This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm.
KW - Behavior
KW - C. elegans
KW - Metals
KW - Neurodegeneration
KW - Neurotransmitters
UR - http://www.scopus.com/inward/record.url?scp=84883501192&partnerID=8YFLogxK
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U2 - 10.3389/fnagi.2013.00018
DO - 10.3389/fnagi.2013.00018
M3 - Review article
C2 - 23730287
AN - SCOPUS:84883501192
SN - 1663-4365
VL - 5
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
IS - MAY
M1 - Article 18
ER -