Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM                         2.5                          exposure in mice

Jian Cui; You Fu; Runze Lu; Yuan Bi; Li Zhang; Chengcheng Zhang; Michael Aschner; Xiaobo Li; Rui Chen

doi:10.1016/j.ecoenv.2018.11.037

Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM _2.5 exposure in mice

Jian Cui, You Fu, Runze Lu, Yuan Bi, Li Zhang, Chengcheng Zhang, Michael Aschner, Xiaobo Li, Rui Chen

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Reproductive epidemiological studies have suggested associations between perinatal exposure to fine particulate matter (PM _2.5 ) and adverse birth outcomes. To explore the effects of early prenatal exposure to PM _2.5 on subsequent generations, pregnant mice were exposed to PM _2.5 or filtered clean air in whole body dynamic exposure chambers for 14 consecutive days from gestation day (GD) 1.5 to GD15.5. Neurobehavioral tests showed that spontaneous locomotion and exploratory behaviors in the offspring were significantly enhanced in the open field test. Meanwhile, metabolomics analysis suggested activation of dopamine pathway while inhibition of glycine pathway in murine brains. Administration of the DRD4 antagonist, clozapine; or supplementation of glycine receptor agonist, taurine, to mice offspring attenuated the locomotor hyperactivities to levels indistinguishable from controls. These data provide strong evidence that maternal exposure to air pollution might increase the risk for neural disorders in the offspring during critical periods of brain development.

Original language	English (US)
Pages (from-to)	687-695
Number of pages	9
Journal	Ecotoxicology and Environmental Safety
Volume	169
DOIs	https://doi.org/10.1016/j.ecoenv.2018.11.037
State	Published - Mar 2019

Keywords

Locomotor activity
Maternal exposure
Metabolomics
PM

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ecoenv.2018.11.037

Cite this

Cui, J., Fu, Y., Lu, R., Bi, Y., Zhang, L., Zhang, C., Aschner, M., Li, X., & Chen, R. (2019). Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM _2.5 exposure in mice Ecotoxicology and Environmental Safety, 169, 687-695. https://doi.org/10.1016/j.ecoenv.2018.11.037

Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM _2.5 exposure in mice . / Cui, Jian; Fu, You; Lu, Runze et al.
In: Ecotoxicology and Environmental Safety, Vol. 169, 03.2019, p. 687-695.

Research output: Contribution to journal › Article › peer-review

Cui, J, Fu, Y, Lu, R, Bi, Y, Zhang, L, Zhang, C, Aschner, M, Li, X & Chen, R 2019, ' Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM _2.5 exposure in mice ', Ecotoxicology and Environmental Safety, vol. 169, pp. 687-695. https://doi.org/10.1016/j.ecoenv.2018.11.037

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title = " Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM 2.5 exposure in mice ",

abstract = " Reproductive epidemiological studies have suggested associations between perinatal exposure to fine particulate matter (PM 2.5 ) and adverse birth outcomes. To explore the effects of early prenatal exposure to PM 2.5 on subsequent generations, pregnant mice were exposed to PM 2.5 or filtered clean air in whole body dynamic exposure chambers for 14 consecutive days from gestation day (GD) 1.5 to GD15.5. Neurobehavioral tests showed that spontaneous locomotion and exploratory behaviors in the offspring were significantly enhanced in the open field test. Meanwhile, metabolomics analysis suggested activation of dopamine pathway while inhibition of glycine pathway in murine brains. Administration of the DRD4 antagonist, clozapine; or supplementation of glycine receptor agonist, taurine, to mice offspring attenuated the locomotor hyperactivities to levels indistinguishable from controls. These data provide strong evidence that maternal exposure to air pollution might increase the risk for neural disorders in the offspring during critical periods of brain development. ",

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author = "Jian Cui and You Fu and Runze Lu and Yuan Bi and Li Zhang and Chengcheng Zhang and Michael Aschner and Xiaobo Li and Rui Chen",

note = "Funding Information: This work was financially supported by the National Key Research and Development (R&D) Plan of China ( 2017YFC0211600 and 2017YFC0211603 ); the Major Research Plan of the National Natural Science Foundation (training program) of China ( 91743112 and 91643109 ); the State Key Program of National Natural Science Foundation of China ( 81730088 ) and Thousand Talent Program for Young Outstanding Scientists of China. MA was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) , USA ( R01 ES10563 , R01 ES07331 and R01 ES020852 ). Funding Information: This work was financially supported by the National Key Research and Development (R&D) Plan of China (2017YFC0211600 and 2017YFC0211603); the Major Research Plan of the National Natural Science Foundation (training program) of China (91743112 and 91643109); the State Key Program of National Natural Science Foundation of China (81730088) and Thousand Talent Program for Young Outstanding Scientists of China. MA was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS), USA (R01 ES10563, R01 ES07331 and R01 ES020852). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Zhang, Li

AU - Zhang, Chengcheng

AU - Aschner, Michael

AU - Li, Xiaobo

AU - Chen, Rui

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