Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action

Jiekun Xuan, Guihua Pan, Yunping Qiu, Lun Yang, Mingming Su, Yumin Liu, Jian Chen, Guoyin Feng, Yiru Fang, Wei Jia, Qinghe Xing, Lin He

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Despite recent advances in understanding the pathophysiology of schizophrenia and the mechanisms of antipsychotic drug action, the development of biomarkers for diagnosis and therapeutic monitoring in schizophrenia remains challenging. Metabolomics provides a powerful approach to discover diagnostic and therapeutic biomarkers by analyzing global changes in an individual's metabolic profile in response to pathophysiological stimuli or drug intervention. In this study, we performed gas chromatography-mass spectrometry based metabolomic profiling in serum of unmedicated schizophrenic patients before and after an 8-week risperidone monotherapy, to detect potential biomarkers associated with schizophrenia and risperidone treatment. Twenty-two marker metabolites contributing to the complete separation of schizophrenic patients from matched healthy controls were identified, with citrate, palmitic acid, myo-inositol, and allantoin exhibiting the best combined classification performance. Twenty marker metabolites contributing to the complete separation between posttreatment and pretreatment patients were identified, with myo-inositol, uric acid, and tryptophan showing the maximum combined classification performance. Metabolic pathways including energy metabolism, antioxidant defense systems, neurotransmitter metabolism, fatty acid biosynthesis, and phospholipid metabolism were found to be disturbed in schizophrenic patients and partially normalized following risperidone therapy. Further study of these metabolites may facilitate the development of noninvasive biomarkers and more efficient therapeutic strategies for schizophrenia.

Original languageEnglish (US)
Pages (from-to)5433-5443
Number of pages11
JournalJournal of Proteome Research
Issue number12
StatePublished - Dec 2 2011
Externally publishedYes


  • atypical antipsychotics
  • gas chromatography-mass spectrometry
  • metabolomics
  • potential biomarkers
  • schizophrenia

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry


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