Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos

Yura Lee, Han Chen, Wei Chen, Qibin Qi, Majid Afshar, Jianwen Cai, Martha L. Daviglus, Bharat Thyagarajan, Kari E. North, Stephanie J. London, Eric Boerwinkle, Juan C. Celedón, Robert C. Kaplan, Bing Yu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the re-lation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the His-panic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10-5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predomi-nantly observed in women (OR = 1.24 and 1.37, p < 0.001) and people of Cuban and Puerto-Rican backgrounds (OR = 1.25 and 1.27, p < 0.01). Mutations in Fatty Acid Desaturase 2 (FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future interven-tion.

Original languageEnglish (US)
Article number359
Issue number4
StatePublished - Apr 2022


  • 1-arachidonoyl-GPA (20:4)
  • Hispanics
  • asthma
  • metabolites
  • metabolomics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology


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