Metabolie labeling of sialic acids in living animals with alkynyl sugars

Pamela V. Chang, Xing Chen, Chris Smyrniotis, Alexander Xenakis, Tianshun Hu, Carolyn R. Bertozzi, Peng Wu

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

Original languageEnglish (US)
Pages (from-to)4030-4033
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number22
StatePublished - May 18 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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