Metabolie labeling of sialic acids in living animals with alkynyl sugars

Pamela V. Chang; Xing Chen; Chris Smyrniotis; Alexander Xenakis; Tianshun Hu; Carolyn R. Bertozzi; Peng Wu

doi:10.1002/anie.200806319

Metabolie labeling of sialic acids in living animals with alkynyl sugars

Pamela V. Chang, Xing Chen, Chris Smyrniotis, Alexander Xenakis, Tianshun Hu, Carolyn R. Bertozzi, Peng Wu

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

Original language	English (US)
Pages (from-to)	4030-4033
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	22
DOIs	https://doi.org/10.1002/anie.200806319
State	Published - May 18 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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abstract = "Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.",

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AU - Smyrniotis, Chris

AU - Xenakis, Alexander

AU - Hu, Tianshun

AU - Bertozzi, Carolyn R.

AU - Wu, Peng

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AB - Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

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Metabolie labeling of sialic acids in living animals with alkynyl sugars

Abstract

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