Metabolic strugGLS after FLT3 inhibition in AML

Samuel J. Taylor; Ulrich Steidl

doi:10.1182/blood-2018-03-836338

Metabolic strugGLS after FLT3 inhibition in AML

Samuel J. Taylor, Ulrich Steidl

Cell Biology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

In this issue of Blood, Gallipoli et al report that by performing an elegant clustered regularly interspaced short palindromic repeats (CRISPR) screen of FLT3 internal tandem duplication–positive (FLT3-ITD¹) acute myeloid leukemia (AML) cells, they have identified that FLT3 inhibition exposes a therapeutically relevant metabolic dependency on glutaminolysis.

Original language	English (US)
Pages (from-to)	1631-1632
Number of pages	2
Journal	Blood
Volume	131
Issue number	15
DOIs	https://doi.org/10.1182/blood-2018-03-836338
State	Published - Apr 12 2018

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2018-03-836338

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title = "Metabolic strugGLS after FLT3 inhibition in AML",

abstract = "In this issue of Blood, Gallipoli et al report that by performing an elegant clustered regularly interspaced short palindromic repeats (CRISPR) screen of FLT3 internal tandem duplication–positive (FLT3-ITD1) acute myeloid leukemia (AML) cells, they have identified that FLT3 inhibition exposes a therapeutically relevant metabolic dependency on glutaminolysis.",

author = "Taylor, {Samuel J.} and Ulrich Steidl",

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AU - Steidl, Ulrich

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AB - In this issue of Blood, Gallipoli et al report that by performing an elegant clustered regularly interspaced short palindromic repeats (CRISPR) screen of FLT3 internal tandem duplication–positive (FLT3-ITD1) acute myeloid leukemia (AML) cells, they have identified that FLT3 inhibition exposes a therapeutically relevant metabolic dependency on glutaminolysis.

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Metabolic strugGLS after FLT3 inhibition in AML

Abstract

ASJC Scopus subject areas

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