TY - JOUR
T1 - Metabolic role of PTEN in insulin signaling and resistance
AU - Li, Yu Zhe
AU - Di Cristofano, Antonio
AU - Woo, Minna
N1 - Funding Information:
M.W.’s research is funded by operating grants from the Canadian Institute of Health Research (MOP-142193) and the Heart and Stroke Foundation of Canada. M.W. holds the Canada Research Chair in Signal Transduction in Diabetes Pathogenesis. A.D.C.’s work referenced in this review is supported by R01 CA128943.
Publisher Copyright:
© 2020 Cold Spring Harbor Laboratory Press; all rights reserved;.
PY - 2020/8
Y1 - 2020/8
N2 - Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tu-morigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the pathogenesis of T2D. PTEN functions in regulating insulin signaling across different organs have been identified. Through the use of a variety of models, such as tissue-specific knockout (KO) mice and in vitro cell cultures, PTEN’s role in regulating insulin action has been elucidated across many cell types. Herein, we will review the recent advancements in the understanding of PTEN’s metabolic functions in each of the tissues and cell types that contribute to regulating systemic insulin sensitivity and discuss how PTEN may represent a promising therapeutic strategy for treatment or prevention of T2D.
AB - Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tu-morigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the pathogenesis of T2D. PTEN functions in regulating insulin signaling across different organs have been identified. Through the use of a variety of models, such as tissue-specific knockout (KO) mice and in vitro cell cultures, PTEN’s role in regulating insulin action has been elucidated across many cell types. Herein, we will review the recent advancements in the understanding of PTEN’s metabolic functions in each of the tissues and cell types that contribute to regulating systemic insulin sensitivity and discuss how PTEN may represent a promising therapeutic strategy for treatment or prevention of T2D.
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U2 - 10.1101/cshperspect.a036137
DO - 10.1101/cshperspect.a036137
M3 - Article
C2 - 31964643
AN - SCOPUS:85089127712
SN - 2157-1422
VL - 10
SP - 1
EP - 17
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 8
M1 - a036137
ER -
