Metabolic role of PTEN in insulin signaling and resistance

Yu Zhe Li, Antonio Di Cristofano, Minna Woo

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tu-morigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the pathogenesis of T2D. PTEN functions in regulating insulin signaling across different organs have been identified. Through the use of a variety of models, such as tissue-specific knockout (KO) mice and in vitro cell cultures, PTEN’s role in regulating insulin action has been elucidated across many cell types. Herein, we will review the recent advancements in the understanding of PTEN’s metabolic functions in each of the tissues and cell types that contribute to regulating systemic insulin sensitivity and discuss how PTEN may represent a promising therapeutic strategy for treatment or prevention of T2D.

Original languageEnglish (US)
Article numbera036137
Pages (from-to)1-17
Number of pages17
JournalCold Spring Harbor Perspectives in Medicine
Issue number8
StatePublished - Aug 2020

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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