TY - JOUR
T1 - Memory Binding Test Predicts Incident Dementia
T2 - Results from the Einstein Aging Study
AU - Mowrey, Wenzhu B.
AU - Lipton, Richard B.
AU - Katz, Mindy J.
AU - Ramratan, Wendy S.
AU - Loewenstein, David A.
AU - Zimmerman, Molly E.
AU - Buschke, Herman
N1 - Publisher Copyright:
© 2018-IOS Press and the authors. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Background: The Memory Binding Test (MBT) demonstrated good cross-sectional discriminative validity and predicted incident aMCI. Objective: To assess whether the MBT predicts incident dementia better than a conventional list learning test in a longitudinal community-based study. Methods: As a sub-study in the Einstein Aging Study, 309 participants age ≥ 70 initially free of dementia were administered the MBT and followed annually for incident dementia for up to 13 years. Based on previous work, poor memory binding was defined using an optimal empirical cut-score of ≥17 on the binding measure of the MBT, Total Items in the Paired condition (TIP). Cox proportional hazards models were used to assess predictive validity adjusting for covariates. We compared the predictive validity ofMBTTIP to that of thefree and cued selectivereminding testfreerecall score(FCSRT-FR; cut-score:≤24) and the single list recall measure of the MBT, Cued Recalled from List 1 (CR-L1; cut-score:≤12). Results: Thirty-five of 309 participants developed incident dementia. When assessing each test alone, the hazard ratio (HR) for dementia was significant for MBT TIP (HR = 8.58, 95% CI: (3.58, 20.58), p < 0.0001), FCSRT-FR (HR = 4.19, 95% CI: (1.94, 9.04), p = 0.0003) and MBT CR-L1 (HR = 2.91, 95% CI: (1.37, 6.18), p = 0.006). MBT TIP remained a significant predictor of dementia (p = 0.0002) when adjusting for FCSRT-FR or CR-L1. Conclusions: Older adults with poor memory binding as measured by the MBT TIP were at increased risk for incident dementia. This measure outperforms conventional episodic memory measures of free and cued recall, supporting the memory binding hypothesis.
AB - Background: The Memory Binding Test (MBT) demonstrated good cross-sectional discriminative validity and predicted incident aMCI. Objective: To assess whether the MBT predicts incident dementia better than a conventional list learning test in a longitudinal community-based study. Methods: As a sub-study in the Einstein Aging Study, 309 participants age ≥ 70 initially free of dementia were administered the MBT and followed annually for incident dementia for up to 13 years. Based on previous work, poor memory binding was defined using an optimal empirical cut-score of ≥17 on the binding measure of the MBT, Total Items in the Paired condition (TIP). Cox proportional hazards models were used to assess predictive validity adjusting for covariates. We compared the predictive validity ofMBTTIP to that of thefree and cued selectivereminding testfreerecall score(FCSRT-FR; cut-score:≤24) and the single list recall measure of the MBT, Cued Recalled from List 1 (CR-L1; cut-score:≤12). Results: Thirty-five of 309 participants developed incident dementia. When assessing each test alone, the hazard ratio (HR) for dementia was significant for MBT TIP (HR = 8.58, 95% CI: (3.58, 20.58), p < 0.0001), FCSRT-FR (HR = 4.19, 95% CI: (1.94, 9.04), p = 0.0003) and MBT CR-L1 (HR = 2.91, 95% CI: (1.37, 6.18), p = 0.006). MBT TIP remained a significant predictor of dementia (p = 0.0002) when adjusting for FCSRT-FR or CR-L1. Conclusions: Older adults with poor memory binding as measured by the MBT TIP were at increased risk for incident dementia. This measure outperforms conventional episodic memory measures of free and cued recall, supporting the memory binding hypothesis.
KW - Aging
KW - Alzheimer's disease
KW - cognition
KW - dementia
KW - longitudinal studies
KW - memory
KW - survival analysis
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U2 - 10.3233/JAD-170714
DO - 10.3233/JAD-170714
M3 - Article
C2 - 29439336
AN - SCOPUS:85048012771
SN - 1387-2877
VL - 62
SP - 293
EP - 304
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -