Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance

George Vlad; Chih Chao Chang; Adriana I. Colovai; Elena R. Vasilescu; Raffaello Cortesini; Nicole Suciu-Foca

doi:10.3109/08830180903281185

Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance

George Vlad, Chih Chao Chang, Adriana I. Colovai, Elena R. Vasilescu, Raffaello Cortesini, Nicole Suciu-Foca

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-κB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3^high tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.

Original language	English (US)
Pages (from-to)	119-132
Number of pages	14
Journal	International Reviews of Immunology
Volume	29
Issue number	2
DOIs	https://doi.org/10.3109/08830180903281185
State	Published - Mar 2010
Externally published	Yes

Keywords

Dendritic cells
ILT receptors
T suppressor cells
Tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3109/08830180903281185

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title = "Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance",

abstract = "The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-κB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3high tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.",

keywords = "Dendritic cells, ILT receptors, T suppressor cells, Tolerance",

author = "George Vlad and Chang, {Chih Chao} and Colovai, {Adriana I.} and Vasilescu, {Elena R.} and Raffaello Cortesini and Nicole Suciu-Foca",

note = "Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation (1-2008-550) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.",

year = "2010",

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doi = "10.3109/08830180903281185",

language = "English (US)",

volume = "29",

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AU - Vlad, George

AU - Chang, Chih Chao

AU - Colovai, Adriana I.

AU - Vasilescu, Elena R.

AU - Cortesini, Raffaello

AU - Suciu-Foca, Nicole

N1 - Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation (1-2008-550) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.

PY - 2010/3

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N2 - The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-κB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3high tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.

AB - The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-κB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3high tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.

KW - Dendritic cells

KW - ILT receptors

KW - T suppressor cells

KW - Tolerance

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JO - International Reviews of Immunology

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Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance

Abstract

Keywords

ASJC Scopus subject areas

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