Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Inmaculada Tasset; Eduardo Agüera; Rosa Olmo-Camacho; Begoña Escribano; Fernando Sánchez-López; María J. Delgado; Antonio H. Cruz; Felix Gascón; Evelio Luque; José Peña; Ignacio M. Jimena; Isaac Túnez

doi:10.1016/j.pnpbp.2011.09.005

Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Inmaculada Tasset, Eduardo Agüera, Rosa Olmo-Camacho, Begoña Escribano, Fernando Sánchez-López, María J. Delgado, Antonio H. Cruz, Felix Gascón, Evelio Luque, José Peña, Ignacio M. Jimena, Isaac Túnez

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

Original language	English (US)
Pages (from-to)	1944-1949
Number of pages	6
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/j.pnpbp.2011.09.005
State	Published - Dec 1 2011
Externally published	Yes

Keywords

Cell damage
Huntington's disease
Melatonin
Neuroplasticity
Neuroprotective
Neurotrophic factors

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2011.09.005

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Tasset, I., Agüera, E., Olmo-Camacho, R., Escribano, B., Sánchez-López, F., Delgado, M. J., Cruz, A. H., Gascón, F., Luque, E., Peña, J., Jimena, I. M., & Túnez, I. (2011). Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(8), 1944-1949. https://doi.org/10.1016/j.pnpbp.2011.09.005

Tasset, I, Agüera, E, Olmo-Camacho, R, Escribano, B, Sánchez-López, F, Delgado, MJ, Cruz, AH, Gascón, F, Luque, E, Peña, J, Jimena, IM & Túnez, I 2011, 'Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 8, pp. 1944-1949. https://doi.org/10.1016/j.pnpbp.2011.09.005

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abstract = "Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.",

keywords = "Cell damage, Huntington's disease, Melatonin, Neuroplasticity, Neuroprotective, Neurotrophic factors",

author = "Inmaculada Tasset and Eduardo Ag{\"u}era and Rosa Olmo-Camacho and Bego{\~n}a Escribano and Fernando S{\'a}nchez-L{\'o}pez and Delgado, {Mar{\'i}a J.} and Cruz, {Antonio H.} and Felix Gasc{\'o}n and Evelio Luque and Jos{\'e} Pe{\~n}a and Jimena, {Ignacio M.} and Isaac T{\'u}nez",

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AU - Agüera, Eduardo

AU - Olmo-Camacho, Rosa

AU - Escribano, Begoña

AU - Sánchez-López, Fernando

AU - Delgado, María J.

AU - Cruz, Antonio H.

AU - Gascón, Felix

AU - Luque, Evelio

AU - Peña, José

AU - Jimena, Ignacio M.

AU - Túnez, Isaac

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N2 - Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

AB - Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

KW - Cell damage

KW - Huntington's disease

KW - Melatonin

KW - Neuroplasticity

KW - Neuroprotective

KW - Neurotrophic factors

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Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Abstract

Keywords

ASJC Scopus subject areas

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