Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Inmaculada Tasset, Eduardo Agüera, Rosa Olmo-Camacho, Begoña Escribano, Fernando Sánchez-López, María J. Delgado, Antonio H. Cruz, Felix Gascón, Evelio Luque, José Peña, Ignacio M. Jimena, Isaac Túnez

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

Original languageEnglish (US)
Pages (from-to)1944-1949
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number8
StatePublished - Dec 1 2011
Externally publishedYes


  • Cell damage
  • Huntington's disease
  • Melatonin
  • Neuroplasticity
  • Neuroprotective
  • Neurotrophic factors

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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