Medical comorbidities in the treatment of epilepsy

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


The treatment of epilepsy extends far beyond seizure control. Many comorbidities have a significant impact on the medical management and quality of life of patients with epilepsy. In this review, we examine interactions between epilepsy and some common medical conditions. Psychiatric disorders with a high prevalence in epilepsy include mood disorders, anxiety disorders, and psychosis. Depression is common, psychosis occurs both in direct relation to seizures and interictally, and suicide rates are increased. Changes in sexual function and reduced fertility and marriage rates are described, including a discussion of polycystic ovary syndrome, which is increased in women with epilepsy. The effects of other chronic medical comorbid conditions are reviewed, including the effects of antiepileptic medications on bone health and the impact of renal insufficiency on pharmacological therapy of epilepsy.

Original languageEnglish (US)
Pages (from-to)S2-S12
JournalEpilepsy and Behavior
Issue numberSUPPL. 2
StatePublished - Oct 2003


  • Cardiovascular
  • Comorbidity
  • Epilepsy
  • Medical
  • Psychiatric
  • Reproduction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


Dive into the research topics of 'Medical comorbidities in the treatment of epilepsy'. Together they form a unique fingerprint.

Cite this