Mediators of the inflammatory response to joint replacement devices

Neil Cobelli, Brian Scharf, Giovanna M. Crisi, John Hardin, Laura Santambrogio

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations


Joint replacement surgery is one of the success stories of modern medicine, restoring mobility, diminishing pain and improving the overall quality of life for millions of people. Unfortunately, wear of these prostheses over time generates debris, which activates an innate immune response that can ultimately lead to periprosthetic resorption of bone (osteolysis) and failure of the implant. Over the past decade, the biological interactions between the particulate debris from various implant materials and the immune system have begun to be better understood. The wear debris induces a multifaceted immune response encompassing the generation of reactive oxygen species and damage-associated molecular patterns, Toll-like receptor signaling and NALP3 inflammasome activation. Acting alone or in concert, these events generate chronic inflammation, periprosthetic bone loss and decreased osteointegration that ultimately leads to implant failure.

Original languageEnglish (US)
Pages (from-to)600-608
Number of pages9
JournalNature Reviews Rheumatology
Issue number10
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Rheumatology


Dive into the research topics of 'Mediators of the inflammatory response to joint replacement devices'. Together they form a unique fingerprint.

Cite this