Abstract
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca2+-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.
Original language | English (US) |
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Pages (from-to) | 1878-1882 |
Number of pages | 5 |
Journal | Science |
Volume | 265 |
Issue number | 5180 |
DOIs | |
State | Published - Sep 23 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- General