Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

Marc G. Weisskopf, Pablo E. Castillo, Robert A. Zalutsky, Roger A. Nicoll

Research output: Contribution to journalArticlepeer-review

492 Scopus citations


Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca2+-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.

Original languageEnglish (US)
Pages (from-to)1878-1882
Number of pages5
Issue number5180
StatePublished - Sep 23 1994
Externally publishedYes

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