TY - JOUR
T1 - Mechanism of ribosome assisted protein folding
T2 - A new insight into rRNA functions
AU - Samanta, Dibyendu
AU - Das, Anindita
AU - Bhattacharya, Arpita
AU - Basu, Arunima
AU - Das, Debasis
AU - DasGupta, Chanchal
N1 - Funding Information:
The authors acknowledge the financial support from CSIR, DST and DBT, Government of India (to C.D.G.) and from CSIR (to D.S.).
PY - 2009/6/26
Y1 - 2009/6/26
N2 - The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.
AB - The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.
KW - Domain V of 23S rRNA
KW - Protein folding by ribosome
KW - Ribosomal exit tunnel
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U2 - 10.1016/j.bbrc.2009.04.106
DO - 10.1016/j.bbrc.2009.04.106
M3 - Short survey
C2 - 19401192
AN - SCOPUS:65549124189
SN - 0006-291X
VL - 384
SP - 137
EP - 140
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -