Maturation and segregation of brain networks that modify seizures

Solomon L. Moshé; Lucy L. Brown; Hana Kubová; Jana Velíšková; R. S. Zukin; Ellen F. Sperber

doi:10.1016/0006-8993(94)91164-9

Maturation and segregation of brain networks that modify seizures

Solomon L. Moshé, Lucy L. Brown, Hana Kubová, Jana Velíšková, R. S. Zukin, Ellen F. Sperber

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Brain research
Volume	665
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(94)91164-9
State	Published - Nov 28 1994

Keywords

Deoxyglucose autoradioraphy
Hybridization, in situ
Infant
Rat
Receptor subunit
Seizure
Substantia nigra
γ-Aminobutyric acid

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)91164-9

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title = "Maturation and segregation of brain networks that modify seizures",

abstract = "The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.",

keywords = "Deoxyglucose autoradioraphy, Hybridization, in situ, Infant, Rat, Receptor subunit, Seizure, Substantia nigra, γ-Aminobutyric acid",

author = "Mosh{\'e}, {Solomon L.} and Brown, {Lucy L.} and Hana Kubov{\'a} and Jana Vel{\'i}{\v s}kov{\'a} and Zukin, {R. S.} and Sperber, {Ellen F.}",

note = "Funding Information: This work was supportedin part by NIH Grants NS-20253( S.L.M.) and NS-20752( R.S.Z.) from the NINDS. We thankD r. A. Tobin for providingu s with the GABAA subunitc DNAs, Ms. Diane Smithf or her technicael xpertisea, nd Mr. Michael Cammeri n the ImageA nalysisF acilityf or his assistance.",

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AU - Moshé, Solomon L.

AU - Brown, Lucy L.

AU - Kubová, Hana

AU - Velíšková, Jana

AU - Zukin, R. S.

AU - Sperber, Ellen F.

N1 - Funding Information: This work was supportedin part by NIH Grants NS-20253( S.L.M.) and NS-20752( R.S.Z.) from the NINDS. We thankD r. A. Tobin for providingu s with the GABAA subunitc DNAs, Ms. Diane Smithf or her technicael xpertisea, nd Mr. Michael Cammeri n the ImageA nalysisF acilityf or his assistance.

PY - 1994/11/28

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N2 - The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.

AB - The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.

KW - Deoxyglucose autoradioraphy

KW - Hybridization, in situ

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KW - Rat

KW - Receptor subunit

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Maturation and segregation of brain networks that modify seizures

Abstract

Keywords

ASJC Scopus subject areas

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