TY - JOUR
T1 - Maternofetal Transmission of AIDS
T2 - Frequency of Human Immunodeficiency Virus Type 1 Nucleic Acid Sequences in Human Fetal DNA
AU - Soeiro, Ruy
AU - Rubinstein, Arye
AU - Rashbaum, William K.
AU - Lyman, William D.
PY - 1992/10
Y1 - 1992/10
N2 - Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-l)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.
AB - Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-l)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.
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U2 - 10.1093/infdis/166.4.699
DO - 10.1093/infdis/166.4.699
M3 - Article
C2 - 1527405
AN - SCOPUS:0026757689
SN - 0022-1899
VL - 166
SP - 699
EP - 703
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -