TY - JOUR
T1 - Mast cells
T2 - A pivotal role in pulmonary fibrosis
AU - Veerappan, Arul
AU - O'Connor, Nathan J.
AU - Brazin, Jacqueline
AU - Reid, Alicia C.
AU - Jung, Albert
AU - McGee, David
AU - Summers, Barbara
AU - Branch-Elliman, Dascher
AU - Stiles, Brendon
AU - Worgall, Stefan
AU - Kaner, Robert J.
AU - Silver, Randi B.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/Wv (MCD) mice and their congenic controls (WBB6F1-+/+). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two mast cell mediators were identified as fibrogenic: histamine and renin, via angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine H 1 and ANG II AT1 receptor subtypes and when activated, they promote proliferation, transforming growth factor β1 secretion, and collagen synthesis. Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of mast cell degranulation and/or histamine and ANG II receptors should attenuate pulmonary fibrosis.
AB - Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/Wv (MCD) mice and their congenic controls (WBB6F1-+/+). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two mast cell mediators were identified as fibrogenic: histamine and renin, via angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine H 1 and ANG II AT1 receptor subtypes and when activated, they promote proliferation, transforming growth factor β1 secretion, and collagen synthesis. Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of mast cell degranulation and/or histamine and ANG II receptors should attenuate pulmonary fibrosis.
UR - http://www.scopus.com/inward/record.url?scp=84876111030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876111030&partnerID=8YFLogxK
U2 - 10.1089/dna.2013.2005
DO - 10.1089/dna.2013.2005
M3 - Article
C2 - 23570576
AN - SCOPUS:84876111030
SN - 1044-5498
VL - 32
SP - 206
EP - 218
JO - DNA and Cell Biology
JF - DNA and Cell Biology
IS - 4
ER -