Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex

D. Raum; D. Glass; C. B. Carpenter; P. H. Schur; C. A. Alper

Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex

D. Raum, D. Glass, C. B. Carpenter, P. H. Schur, C. A. Alper

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Abstract

Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meisoses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.

Original language	English (US)
Pages (from-to)	35-41
Number of pages	7
Journal	American Journal of Human Genetics
Volume	31
Issue number	1
State	Published - Dec 17 1979
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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abstract = "Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meisoses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.",

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AU - Raum, D.

AU - Glass, D.

AU - Carpenter, C. B.

AU - Schur, P. H.

AU - Alper, C. A.

PY - 1979/12/17

Y1 - 1979/12/17

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AB - Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meisoses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.

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Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex

Abstract

ASJC Scopus subject areas

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