Manganese neurotoxicity and the role of reactive oxygen species

Ebany J. Martinez-Finley, Claire E. Gavin, Michael Aschner, Thomas E. Gunter

Research output: Contribution to journalReview articlepeer-review

223 Scopus citations


Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalFree Radical Biology and Medicine
StatePublished - 2013
Externally publishedYes


  • DA autoxidation
  • Free radicals
  • Manganese
  • Manganism
  • Mitochondrial dysfunction
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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