Manganese neurotoxicity

Daiana Silva Ávila; Robson Luiz Puntel; Vanderlei Folmer; João Batista Teixeira Rocha; Ana Paula Marreilha dos Santos; Michael Aschner

doi:10.1007/978-1-4614-5836-4_3

Manganese neurotoxicity

Daiana Silva Ávila, Robson Luiz Puntel, Vanderlei Folmer, João Batista Teixeira Rocha, Ana Paula Marreilha dos Santos, Michael Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Abstract

Over the past years there has been considerable progress in our understanding of manganese (Mn)-induced neurotoxicity and its mechanisms. These studies led to changes in Mn safety assessment around the world. However, manganism continues to represent a health concern, especially considering the recent findings linking manganism to Parkinson's disease (PD). Animal models have been invaluable in these investigations. Findings from these studies are discussed in this chapter within the context of Mn-induced neurotoxicity mechanisms and its role in the etiology of parkinsonism.

Original language	English (US)
Title of host publication	Handbook of Neurotoxicity
Publisher	Springer New York
Pages	843-864
Number of pages	22
Volume	2
ISBN (Electronic)	9781461458364
ISBN (Print)	9781461458357
DOIs	https://doi.org/10.1007/978-1-4614-5836-4_3
State	Published - Jan 1 2014

Keywords

Dopamine
Manganese
Neurotoxicity
Parkinson's disease

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Access to Document

10.1007/978-1-4614-5836-4_3

Cite this

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AU - Ávila, Daiana Silva

AU - Puntel, Robson Luiz

AU - Folmer, Vanderlei

AU - Rocha, João Batista Teixeira

AU - dos Santos, Ana Paula Marreilha

AU - Aschner, Michael

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AB - Over the past years there has been considerable progress in our understanding of manganese (Mn)-induced neurotoxicity and its mechanisms. These studies led to changes in Mn safety assessment around the world. However, manganism continues to represent a health concern, especially considering the recent findings linking manganism to Parkinson's disease (PD). Animal models have been invaluable in these investigations. Findings from these studies are discussed in this chapter within the context of Mn-induced neurotoxicity mechanisms and its role in the etiology of parkinsonism.

KW - Dopamine

KW - Manganese

KW - Neurotoxicity

KW - Parkinson's disease

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ER -

Manganese neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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