TY - JOUR
T1 - Manganese-induced parkinsonism and Parkinson’s disease
T2 - Shared and distinguishable features
AU - Kwakye, Gunnar F.
AU - Paoliello, Monica M.B.
AU - Mukhopadhyay, Somshuvra
AU - Bowman, Aaron B.
AU - Aschner, Michael
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/7/6
Y1 - 2015/7/6
N2 - Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson’s disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson’s disease (PD).
AB - Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson’s disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson’s disease (PD).
KW - Manganese neurotoxicity
KW - Manganese-induced parkinsonism
KW - Manganism
KW - Neurodegenerative diseases
KW - Parkinson’s disease (PD)
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U2 - 10.3390/ijerph120707519
DO - 10.3390/ijerph120707519
M3 - Review article
C2 - 26154659
AN - SCOPUS:84939483585
SN - 1661-7827
VL - 12
SP - 7519
EP - 7540
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 7
ER -
