TY - JOUR
T1 - Manganese homeostasis in the nervous system
AU - Chen, Pan
AU - Chakraborty, Sudipta
AU - Mukhopadhyay, Somshuvra
AU - Lee, Eunsook
AU - Paoliello, Monica M.B.
AU - Bowman, Aaron B.
AU - Aschner, Michael
N1 - Publisher Copyright:
© 2015 International Society for Neurochemistry.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn-induced neurotoxicity.
AB - Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn-induced neurotoxicity.
KW - Parkinson's disease
KW - manganese
KW - transport
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U2 - 10.1111/jnc.13170
DO - 10.1111/jnc.13170
M3 - Review article
C2 - 25982296
AN - SCOPUS:84937813455
SN - 0022-3042
VL - 134
SP - 601
EP - 610
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 4
ER -