MAL63 codes for a positive regulator of maltose fermentation in Saccharomyces cerevisiae

Young Sook Change, Robert A. Dubin, Edward Perkins, Doug Forrest, Corinne A. Michels, Richard B. Needleman

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Genetic analysis of the MAL6 locus has previously yielded mal6 mutants which fall into a single complementation group and which are noninducible for maltase and maltose permease. However, the strains used in these studies contained additional partially functional copies of MAL1 (referred to as MAL1g) and MAL3 (referred to as MAL3g). Using a strain lacking MALg genes, we have isolated two classes of mutants and these classes correspond to mutations in MAL63 and MAL61, two genes of the MAL6 complex. Disruptions of MAL63 are noninducible for maltase and maltose permease and for their corresponding mRNAs. The mal6 mutants are shown to map to MAL63 Inducer exclusion as a cause of the noninducible phenotype of the mal63 mutations has been eliminated by constructing a ma163 mutant in a strain constitutive for maltose permease; the strain remains noninducible. These results rigorously demonstrate that MAL63 is a regulatory gene which plays a positive role in the regulation of maltose fermentation.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalCurrent Genetics
Issue number3
StatePublished - Sep 1 1988
Externally publishedYes


  • MAL6
  • MAL63
  • Maltose fermentation
  • Positive regulation
  • Saccharomyces

ASJC Scopus subject areas

  • Genetics


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