Major Resection for Chronic Pancreatitis

John C. Mcauliffe, John D. Christein

Research output: Chapter in Book/Report/Conference proceedingChapter


There is no standard of therapy for chronic pancreatitis, and it can be managed with multiple combinations of modalities. Several different types of operative treatment are used typically when other modalities fail. The goal of operative intervention is removal of the nidus of disease and/or drainage of the pancreatic duct in order to improve quality of life by relieving pain. Major resections include pancreatoduodenectomy, distal pancreatectomy, and total pancreatectomy. Of particular concern for patients with chronic pancreatitis is the diabetes that can be precipitated by resection. Islet-cell autotransplantation has shown promise in ameliorating the natural history of the diabetes after pancreatectomy in chronic pancreatitis. Operative intervention for chronic pancreatitis should be performed by experienced surgeons at high-volume institutions to provide the most favorable outcomes and follow-up.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer, Cystic Neoplasms and Endocrine Tumors
Subtitle of host publicationDiagnosis and Management
Number of pages5
ISBN (Electronic)9781118307816
ISBN (Print)9780470673188
StatePublished - Apr 7 2015
Externally publishedYes


  • Chronic pancreatitis
  • Distal
  • Islet-cell transplantation
  • Pancreatoduodenectomy
  • Total

ASJC Scopus subject areas

  • General Medicine


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