@inbook{f54e05f7f3b5455a92404122045e6c17,
title = "Magnetic resonance imaging in experimental traumatic brain injury",
abstract = "Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. Common causes of TBI include falls, violence, injuries from wars, and vehicular and sporting accidents. The initial direct mechanical damage in TBI is followed by progressive secondary injuries such as brain swelling, perturbed cerebral blood flow (CBF), abnormal cerebrovascular reactivity (CR), metabolic dysfunction, blood–brain-barrier disruption, inflammation, oxidative stress, and excitotoxicity, among others. Magnetic resonance imaging (MRI) offers the means to noninvasively probe many of these secondary injuries. MRI has been used to image anatomical, physiological, and functional changes associated with TBI in a longitudinal manner. This chapter describes controlled cortical impact (CCI) TBI surgical procedures, a few common MRI protocols used in TBI imaging, and, finally, image analysis pertaining to experimental TBI imaging in rats.",
keywords = "ADC, BBB, CBF, DWI, Experimental TBI model, MRI, PWI, Rodents, Traumatic brain injury, fMRI",
author = "Qiang Shen and Watts, {Lora Tally} and Wei Li and Duong, {Timothy Q.}",
note = "Funding Information: This work is supported in part by NIH/NINDS R01 NS45879, a TL1 and KL2 TR001118, and Mike Hogg Fund via the Clinical Translational Science Awards (CTSA, parent grants UL1TR000149, TL1TR001119, and KL2TR001118). We thank our former and current colleagues who have participated on these TBI projects. Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
doi = "10.1007/978-1-4939-3816-2_35",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "645--658",
booktitle = "Methods in Molecular Biology",
}
