Lysosomal compromise and brain dysfunction: Examining the role of neuroaxonal dystrophy

Steven U. Walkley, Jakub Sikora, Matthew Micsenyi, Cristin Davidson, Kostantin Dobrenis

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Lysosomal diseases are a family of over 50 disorders caused by defects in proteins critical for normal function of the endosomal/lysosomal system and characterized by complex pathogenic cascades involving progressive dysfunction of many organ systems, most notably the brain. Evidence suggests that compromise in lysosomal function is highly varied and leads to changes in multiple substrate processing and endosomal signalling, in calcium homoeostasis and endoplasmic reticulum stress, and in autophagocytosis and proteasome function. Neurons are highly vulnerable and show abnormalities in perikarya, dendrites and axons, often in ways seemingly unrelated to the primary lysosomal defect. A notable example is NAD (neuroaxonal dystrophy), which is characterized by formation of focal enlargements (spheroids) containing diverse organelles and other components consistent with compromise of retrograde axonal transport. Although neurons may be universally susceptible to NAD, GABAergic neurons, particularly Purkinje cells, appear most vulnerable and ataxia and related features of cerebellar dysfunction are a common outcome. As NAD is found early in disease and thus may be a contributor to Purkinje cell dysfunction and death, understanding its link to lysosomal compromise could lead to therapies designed to prevent its occurrence and thereby ameliorate cerebellar dysfunction.

Original languageEnglish (US)
Pages (from-to)1436-1441
Number of pages6
JournalBiochemical Society transactions
Issue number6
StatePublished - Dec 2010


  • Autophagy
  • Axonal spheroid
  • Axoplasmic transport
  • Lysosomal disease
  • Niemann-Pick type C disease
  • Purkinje cell

ASJC Scopus subject areas

  • Biochemistry


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