Lower Genital Tract Microbiome in Early Pregnancy in the Eastern European Population

Mariya Gryaznova, Olga Lebedeva, Olesya Kozarenko, Yuliya Smirnova, Inna Burakova, Mikhail Syromyatnikov, Alexander Maslov, Vasily Popov

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: It is known that the features of the cervicovaginal microbiome can depend on ethnicity, which might be caused by genetic factors, as well as differences in diet and lifestyle. There is no research on the cervicovaginal microbiome of Eastern European women during early pregnancy. Methods: We evaluated the cervical and cervicovaginal microbiome of women with first-trimester pregnancy (n = 22), further delivered at term, using the 16S rRNA sequencing method. Results: The predominant bacterial species in both groups was Lactobacillus iners, followed by Prevotella copri, Ileibacterium valens, Gardnerella vaginalis and Muribaculum intestinale in the cervical samples, and Gardnerella vaginalis, Prevotella copri, Bifidobacterium longum, Ileibacterium valens and Muribaculum intestinale in the cervicovaginal samples. The cervical microbiome had higher alpha diversity; a higher abundance of Muribaculum intestinale, Aquabacterium parvum and Methyloversatilis universalis; and a lower abundance of Psychrobacillus psychrodurans. Conclusions: The Lactobacillus iners-dominated microbiome (CST III) was the predominant type of cervical and cervicovaginal microbiome in early pregnancy in the majority of the women. The presence of soil and animal bacteria in the cervicovaginal microbiome can be explained by the rural origin of patients.

Original languageEnglish (US)
Article number2368
JournalMicroorganisms
Volume10
Issue number12
DOIs
StatePublished - Dec 2022

Keywords

  • 16S rRNA
  • Lactobacillus inners
  • NGS
  • cervical microbiome
  • early pregnancy
  • female genital tract
  • first trimester
  • sequencing
  • vaginal microbiome

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology

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