Low serum IgA and airway injury in World Trade Center-exposed firefighters: A 17-year longitudinal study

Barbara Putman; Lies Lahousse; Rachel Zeig-Owens; Ankura Singh; Charles B. Hall; Yang Liu; Theresa Schwartz; David Goldfarb; Mayris P. Webber; David J. Prezant; Michael D. Weiden

doi:10.1136/thoraxjnl-2019-213715

Low serum IgA and airway injury in World Trade Center-exposed firefighters: A 17-year longitudinal study

Barbara Putman, Lies Lahousse, Rachel Zeig-Owens, Ankura Singh, Charles B. Hall, Yang Liu, Theresa Schwartz, David Goldfarb, Mayris P. Webber, David J. Prezant, Michael D. Weiden

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV 1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV 1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.

Original language	English (US)
Pages (from-to)	1182-1184
Number of pages	3
Journal	Thorax
Volume	74
Issue number	12
DOIs	https://doi.org/10.1136/thoraxjnl-2019-213715
State	Published - Dec 1 2019

Keywords

COPD Exacerbations
occupational lung disease

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2019-213715

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@article{04d551ed2ca649d9bfa4aecf8cc70b9f,

title = "Low serum IgA and airway injury in World Trade Center-exposed firefighters: A 17-year longitudinal study",

abstract = "Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV 1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV 1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.",

keywords = "COPD Exacerbations, occupational lung disease",

author = "Barbara Putman and Lies Lahousse and Rachel Zeig-Owens and Ankura Singh and Hall, {Charles B.} and Yang Liu and Theresa Schwartz and David Goldfarb and Webber, {Mayris P.} and Prezant, {David J.} and Weiden, {Michael D.}",

note = "Funding Information: Competing interests BP, RZ-O, AS, CBH, YL, TS, DG, MPW, DJP and MDW report grants and/or contracts from the National Institute of Occupational Safety and Health, during the conduct of the study and outside the submitted work. LL reports grants from AstraZeneca and Chiesi (both awards), and expert consultation for Boehringer Ingelheim GmbH and Novartis outside the submitted work. Funding Information: Funding This research was funded by National Institute for Occupational Safety and Health, grant number U01 OH011302, U01OH011682 and contracts #200-2011-39383, #200-2011-39378, #200-2017-93426 and #200-2017-93326. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2019.",

year = "2019",

month = dec,

day = "1",

doi = "10.1136/thoraxjnl-2019-213715",

language = "English (US)",

volume = "74",

pages = "1182--1184",

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T1 - Low serum IgA and airway injury in World Trade Center-exposed firefighters

T2 - A 17-year longitudinal study

AU - Putman, Barbara

AU - Lahousse, Lies

AU - Zeig-Owens, Rachel

AU - Singh, Ankura

AU - Hall, Charles B.

AU - Liu, Yang

AU - Schwartz, Theresa

AU - Goldfarb, David

AU - Webber, Mayris P.

AU - Prezant, David J.

AU - Weiden, Michael D.

N1 - Funding Information: Competing interests BP, RZ-O, AS, CBH, YL, TS, DG, MPW, DJP and MDW report grants and/or contracts from the National Institute of Occupational Safety and Health, during the conduct of the study and outside the submitted work. LL reports grants from AstraZeneca and Chiesi (both awards), and expert consultation for Boehringer Ingelheim GmbH and Novartis outside the submitted work. Funding Information: Funding This research was funded by National Institute for Occupational Safety and Health, grant number U01 OH011302, U01OH011682 and contracts #200-2011-39383, #200-2011-39378, #200-2017-93426 and #200-2017-93326. Publisher Copyright: © Author(s) (or their employer(s)) 2019.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV 1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV 1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.

AB - Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV 1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV 1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.

KW - COPD Exacerbations

KW - occupational lung disease

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JO - Thorax

JF - Thorax

IS - 12

ER -

Low serum IgA and airway injury in World Trade Center-exposed firefighters: A 17-year longitudinal study

Abstract

Keywords

ASJC Scopus subject areas

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