Low-grade glioma: A rare second tumor in retinoblastoma survivors

Nagma Dalvi; Ruth A. Kleinerman; Sidnei Epelman; David H. Abramson; Ira J. Dunkel

doi:10.1002/pbc.28770

Low-grade glioma: A rare second tumor in retinoblastoma survivors

Nagma Dalvi, Ruth A. Kleinerman, Sidnei Epelman, David H. Abramson, Ira J. Dunkel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.

Original language	English (US)
Article number	e28770
Journal	Pediatric Blood and Cancer
Volume	68
Issue number	2
DOIs	https://doi.org/10.1002/pbc.28770
State	Published - Feb 2021
Externally published	Yes

Keywords

low-grade glioma
retinoblastoma
second cancers
survivorship

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.28770

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title = "Low-grade glioma: A rare second tumor in retinoblastoma survivors",

abstract = "Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.",

keywords = "low-grade glioma, retinoblastoma, second cancers, survivorship",

author = "Nagma Dalvi and Kleinerman, {Ruth A.} and Sidnei Epelman and Abramson, {David H.} and Dunkel, {Ira J.}",

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year = "2021",

month = feb,

doi = "10.1002/pbc.28770",

language = "English (US)",

volume = "68",

journal = "Pediatric Blood and Cancer",

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T1 - Low-grade glioma

T2 - A rare second tumor in retinoblastoma survivors

AU - Dalvi, Nagma

AU - Kleinerman, Ruth A.

AU - Epelman, Sidnei

AU - Abramson, David H.

AU - Dunkel, Ira J.

PY - 2021/2

Y1 - 2021/2

N2 - Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.

AB - Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.

KW - low-grade glioma

KW - retinoblastoma

KW - second cancers

KW - survivorship

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DO - 10.1002/pbc.28770

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AN - SCOPUS:85092645422

SN - 1545-5009

VL - 68

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 2

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ER -

Low-grade glioma: A rare second tumor in retinoblastoma survivors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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