Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

Sushil Pandey; Catherine Vilchèze; Jim Werngren; Arnold Bainomugisa; Mikael Mansjö; Ramona Groenheit; Paolo Miotto; Daniela M. Cirillo; Christopher Coulter; Alain R. Baulard; Thomas Schön; William R. Jacobs; Kamel Djaout; Claudio U. Köser

doi:10.1128/aac.01096-23

Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

Sushil Pandey, Catherine Vilchèze, Jim Werngren, Arnold Bainomugisa, Mikael Mansjö, Ramona Groenheit, Paolo Miotto, Daniela M. Cirillo, Christopher Coulter, Alain R. Baulard, Thomas Schön, William R. Jacobs, Kamel Djaout, Claudio U. Köser

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Results from clinical strains and knockouts of the H37Rv and CDC1551 laboratory strains demonstrated that ndh (Rv1854c) is not a resistance-conferring gene for isoniazid, ethionamide, delamanid, or pretomanid in Mycobacterium tuberculosis. This difference in the susceptibility to NAD-adduct-forming drugs compared with other mycobacteria may be driven by differences in the absolute intrabacterial NADH concentration.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	68
Issue number	1
DOIs	https://doi.org/10.1128/aac.01096-23
State	Published - Jan 2024

Keywords

Mycobacterium tuberculosis
delamanid
ethionamide
isoniazid
pretomanid

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/aac.01096-23

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Pandey, S., Vilchèze, C., Werngren, J., Bainomugisa, A., Mansjö, M., Groenheit, R., Miotto, P., Cirillo, D. M., Coulter, C., Baulard, A. R., Schön, T., Jacobs, W. R., Djaout, K., & Köser, C. U. (2024). Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 68(1). https://doi.org/10.1128/aac.01096-23

Pandey, S, Vilchèze, C, Werngren, J, Bainomugisa, A, Mansjö, M, Groenheit, R, Miotto, P, Cirillo, DM, Coulter, C, Baulard, AR, Schön, T, Jacobs, WR, Djaout, K & Köser, CU 2024, 'Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis', Antimicrobial agents and chemotherapy, vol. 68, no. 1. https://doi.org/10.1128/aac.01096-23

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AU - Werngren, Jim

AU - Bainomugisa, Arnold

AU - Mansjö, Mikael

AU - Groenheit, Ramona

AU - Miotto, Paolo

AU - Cirillo, Daniela M.

AU - Coulter, Christopher

AU - Baulard, Alain R.

AU - Schön, Thomas

AU - Jacobs, William R.

AU - Djaout, Kamel

AU - Köser, Claudio U.

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Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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