Loss of Ascorbic Acid from Injured Feline Spinal Cord

Dennis D. Pietronigro; Movses Hovsepian; Harry B. Demopoulos; Eugene S. Flamm

doi:10.1111/j.1471-4159.1983.tb09053.x

Loss of Ascorbic Acid from Injured Feline Spinal Cord

Dennis D. Pietronigro, Movses Hovsepian, Harry B. Demopoulos, Eugene S. Flamm

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Abstract: Feline spinal cord contains 0.97 mM ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h. Following contusion injury severe enough to produce paraplegia, ascorbic acid is rapidly lost from injured spinal tissue. Thus, ascorbic acid is decreased 30% by 1 h and 50% by 3 h following injury. Oxidized ascorbic acid is increased at 1, but not 3, h following impact. As a consequence of its many functions in CNS, loss of ascorbic acid may contribute to derangements in spinal cord function following injury.

Original language	English (US)
Pages (from-to)	1072-1076
Number of pages	5
Journal	Journal of Neurochemistry
Volume	41
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1983.tb09053.x
State	Published - Apr 1983
Externally published	Yes

Keywords

Ascorbic acid
Spinal cord injury

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1983.tb09053.x

Cite this

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title = "Loss of Ascorbic Acid from Injured Feline Spinal Cord",

abstract = "Abstract: Feline spinal cord contains 0.97 mM ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h. Following contusion injury severe enough to produce paraplegia, ascorbic acid is rapidly lost from injured spinal tissue. Thus, ascorbic acid is decreased 30% by 1 h and 50% by 3 h following injury. Oxidized ascorbic acid is increased at 1, but not 3, h following impact. As a consequence of its many functions in CNS, loss of ascorbic acid may contribute to derangements in spinal cord function following injury.",

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AU - Pietronigro, Dennis D.

AU - Hovsepian, Movses

AU - Demopoulos, Harry B.

AU - Flamm, Eugene S.

PY - 1983/4

Y1 - 1983/4

N2 - Abstract: Feline spinal cord contains 0.97 mM ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h. Following contusion injury severe enough to produce paraplegia, ascorbic acid is rapidly lost from injured spinal tissue. Thus, ascorbic acid is decreased 30% by 1 h and 50% by 3 h following injury. Oxidized ascorbic acid is increased at 1, but not 3, h following impact. As a consequence of its many functions in CNS, loss of ascorbic acid may contribute to derangements in spinal cord function following injury.

AB - Abstract: Feline spinal cord contains 0.97 mM ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h. Following contusion injury severe enough to produce paraplegia, ascorbic acid is rapidly lost from injured spinal tissue. Thus, ascorbic acid is decreased 30% by 1 h and 50% by 3 h following injury. Oxidized ascorbic acid is increased at 1, but not 3, h following impact. As a consequence of its many functions in CNS, loss of ascorbic acid may contribute to derangements in spinal cord function following injury.

KW - Ascorbic acid

KW - Spinal cord injury

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Loss of Ascorbic Acid from Injured Feline Spinal Cord

Abstract

Keywords

ASJC Scopus subject areas

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