TY - JOUR
T1 - Loss of antigenic epitopes as the result of env gene recombination in retrovirus-induced leukemia in immunocompetent mice
AU - Tumas, Kathleen M.
AU - Poszgay, Judith M.
AU - Avidan, Nili
AU - Ksiazek, Stephen J.
AU - Overmoyer, Beth
AU - Blank, Kenneth J.
AU - Prystowsky, Michael B.
PY - 1993/2
Y1 - 1993/2
N2 - The murine leukemia virus, E-55+ virus, induces a thymic lymphoma/leukemia in 100% of BALB.K mice infected as adults after a latent period of 4 months or more (Pozsgay et al., Virology 173, 330-334, 1989). Two molecular clones of virus designated E-55+ and E-55— based on their ability to encode the E-55 epitope detected by the monoclonal antibody 55 (mAb 55) were isolated from a leukemic BALB.K mouse inoculated with a biologically cloned E-55+ virus (Chesebro et al., Virology 112, 131-144, 1981). Env gene sequence analysis of E-55+ and E-55— clones showed that the E-55— virus was generated from the E-55+ virus as the result of a recombination between E-55+ virus and the endogenous ecotropic virus, emv-1, carried in the genome of the BALB.K mouse strain. The recombinant E-55— virus is replication competent. This recombination event and the consequential expression of E-55— virus consistently occur in immunocompetent BALB.K mice inoculated with the E-55+ virus and appear to play a role in the loss of epitopes recognized by virus neutralizing antibodies. The loss of these epitopes apparently allows the virus to evade the host immune response.
AB - The murine leukemia virus, E-55+ virus, induces a thymic lymphoma/leukemia in 100% of BALB.K mice infected as adults after a latent period of 4 months or more (Pozsgay et al., Virology 173, 330-334, 1989). Two molecular clones of virus designated E-55+ and E-55— based on their ability to encode the E-55 epitope detected by the monoclonal antibody 55 (mAb 55) were isolated from a leukemic BALB.K mouse inoculated with a biologically cloned E-55+ virus (Chesebro et al., Virology 112, 131-144, 1981). Env gene sequence analysis of E-55+ and E-55— clones showed that the E-55— virus was generated from the E-55+ virus as the result of a recombination between E-55+ virus and the endogenous ecotropic virus, emv-1, carried in the genome of the BALB.K mouse strain. The recombinant E-55— virus is replication competent. This recombination event and the consequential expression of E-55— virus consistently occur in immunocompetent BALB.K mice inoculated with the E-55+ virus and appear to play a role in the loss of epitopes recognized by virus neutralizing antibodies. The loss of these epitopes apparently allows the virus to evade the host immune response.
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U2 - 10.1006/viro.1993.1075
DO - 10.1006/viro.1993.1075
M3 - Article
C2 - 7678475
AN - SCOPUS:0027221170
SN - 0042-6822
VL - 192
SP - 587
EP - 595
JO - Virology
JF - Virology
IS - 2
ER -